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Tam, Wayne

0000-0003-4283-0005

Mayo Clinic

Department of Pathology, Northwell Health, New York, NY, USA.

Citations 2

DNA mismatch repair defect and intratumor heterogeneous deficiency differently impact immune responses in diffuse large B-cell lymphoma

OncoImmunology | August 5, 2024 | Volume: 13 | Issue: 1 | Pages: No page available

10.1080/2162402x.2024.2384667 | PMID 39108501

Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, combined with azacitidine in patients with AML

Blood | January 18, 2018 | Volume: 131 | Issue: 13 | Pages: 1415-1424

10.1182/blood-2017-09-805895 | PMID 29348128

Key Points RP2D of PEV 20 mg/m2 in PEV/AZA combo did not alter toxicity profile of AZA; dose-limiting toxicities were transiently elevated AST/ALT. In treatment-naive older AML patients, the intent-to-treat ORR was 50%.