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Lee, Kelvin P

0000-0003-2587-0734

Mayo Clinic

Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY; Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY.

Citations 1

CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myeloma

Blood | April 30, 2014 | Volume: 123 | Issue: 24 | Pages: 3770-3779

10.1182/blood-2013-10-530964 | PMID 24782505

Key PointsCD28 delivers a pro-survival signal to MM cells via regulation of PI3K/Akt, FoxO3a, and Bim. Blockade of CD28:CD80/CD86 in vivo resensitizes MM cells to chemotherapy and significantly reduces tumor burden.