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Nho, Kwangsik T.

0000-0002-7624-3872

A5087302585 | I4394709130

Mayo Clinic

Indiana University School of Medicine

Citations 49

P3‐018: INFLUENCE OF RARE PSEN1 VARIANTS ON QUANTITATIVE STRUCTURAL IMAGING AND CSF PHENOTYPES IN LATE ONSET ALZHEIMER'S DISEASE

Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_17 | Pages: No page available

10.1016/j.jalz.2014.05.1105

IC‐P‐096: INCREASED AMYLOID DEPOSITION IN OLDER ADULTS AT RISK FOR PROGRESSION TO ALZHEIMER'S DISEASE DUE TO GENETIC BACKGROUND AND/OR THE PRESENCE OF SIGNIFICANT MEMORY CONCERNS

Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_6 | Pages: No page available

10.1016/j.jalz.2014.05.101

O3‐03‐02: TWO‐YEAR LONGITUDINAL CHANGE IN AMYLOID DEPOSITION, GLUCOSE METABOLISM, AND HIPPOCAMPAL ATROPHY IN ADNI‐2 PARTICIPANTS: RELATION TO GENETIC RISK

Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_3 | Pages: No page available

10.1016/j.jalz.2014.04.281

P3‐024: NEXT‐GENERATION SEQUENCING OF THE BCHE LOCUS IDENTIFIES A FUNCTIONAL SNP ASSOCIATED WITH ALZHEIMER'S DISEASE BIOMARKERS AND AGE OF ONSET

Alzheimer's & Dementia | September 6, 2014 | Volume: 10 | Issue: 4S_Part_17 | Pages: No page available

10.1016/j.jalz.2014.05.1111

P4‐335: Integrating whole‐exome sequencing and imaging genetics to identify single‐nucleotide variants associated with rate of hippocampal neurodegeneration in APOE‐ε3/ε3 males with mild cognitive impairment

Alzheimer's & Dementia | March 29, 2014 | Volume: 8 | Issue: 4S_Part_21 | Pages: No page available

10.1016/j.jalz.2013.08.116

O3–01–03: Protective variant for rate of hippocampal volume loss identified by whole exome sequencing in APOE‐ε3ε3 males with MCI

Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_13 | Pages: No page available

10.1016/j.jalz.2013.04.238

P3–008: Genome‐wide analysis of genetic variants associated with depressive symptoms in older adults

Alzheimer's & Dementia | October 9, 2013 | Volume: 9 | Issue: 4S_Part_14 | Pages: No page available

10.1016/j.jalz.2013.05.1077

O4‐03‐06: The role of APOE genotype in early mild cognitive impairment (E‐MCI): Preliminary results from ADNI‐2

Alzheimer's & Dementia | July 19, 2012 | Volume: 8 | Issue: 4S_Part_17 | Pages: No page available

10.1016/j.jalz.2012.05.1651

Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans

Alzheimer's & Dementia | May 7, 2010 | Volume: 6 | Issue: 3 | Pages: 265-273

10.1016/j.jalz.2010.03.013 | PMID 20451875

The role of the Alzheimer's Disease Neuroimaging Initiative Genetics Core is to facilitate the investigation of genetic influences on disease onset and trajectory as reflected in structural, functional, and molecular imaging changes; fluid biomarkers; and cognitive status. Major goals include (1) blood sample processing, genotyping, and dissemination, (2) genome‐wide association studies (GWAS) of longitudinal phenotypic data, and (3) providing a central resource, point of contact and planning group for genetics within the Alzheimer's Disease Neuroimaging Initiative. Genome‐wide array data have been publicly released and updated, and several neuroimaging GWAS have recently been reported examining baseline magnetic resonance imaging measures as quantitative phenotypes. Other preliminary investigations include copy number variation in mild cognitive impairment and Alzheimer's disease and GWAS of baseline cerebrospinal fluid biomarkers and longitudinal changes on magnetic resonance imaging. Blood collection for RNA studies is a new direction. Genetic studies of longitudinal phenotypes hold promise for elucidating disease mechanisms and risk, development of therapeutic strategies, and refining selection criteria for clinical trials.