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Prakash, Y. S.

https://orcid.org/0000-0002-2968-224X

A5079580565 | I1330342723

Mayo Clinic

Mayo Clinic

Citations 329

Spatial Profiling of Bronchial Airways in Asthma and COPD

A99. LOOKING UNDER THE HOOD: DIAGNOSTIC TOOLS TO PHENOTYPE SEVERE ASTHMA | April 30, 2024 | Volume: No volume available | Issue: No issue available | Pages: A2777-A2777

10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2777

Hydrogen Sulfide (H 2 S) Alleviates Effects of Hyperoxia on Mitochondrial Structure and Function in Human Developing Airway Smooth Muscle

C20. HAVING A GROWTH MINDSET: REPROGRAMMING CELLULAR PATHWAYS TO DISEASE | April 30, 2024 | Volume: No volume available | Issue: No issue available | Pages: A5024-A5024

10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5024

Significance of Adma Levels in Patients With Pulmonary Hypertension and Chronic Kidney Disease

B60. CYANOTIC PACIFIC BLUE: GROUP 3 PH AND HYPOXIC LUNG DISEASE | April 30, 2024 | Volume: No volume available | Issue: No issue available | Pages: A4019-A4019

10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4019

Activation of Aryl Hydrocarbon Receptor Inhibits Extracellular Matrix in Airway Smooth Muscle Cells

B79. AIRWAY SMOOTH MUSCLE IN ASTHMA | April 30, 2024 | Volume: No volume available | Issue: No issue available | Pages: A4479-A4479

10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4479

KISS1R Activation Alters Intracellular Calcium in Airway Smooth Muscle During Inflammation: Th2 Biased Effect

B79. AIRWAY SMOOTH MUSCLE IN ASTHMA | April 30, 2024 | Volume: No volume available | Issue: No issue available | Pages: A4475-A4475

10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4475

2-hydroxyestradiol (2HE) Attenuates the Airway Remodeling Via Activation of ERβ Receptor in Airway Smooth Muscle

B79. AIRWAY SMOOTH MUSCLE IN ASTHMA | April 30, 2024 | Volume: No volume available | Issue: No issue available | Pages: A4474-A4474

10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4474

Activation of KISS1R Inhibits Mitogen Induced Airway Smooth Muscle Cell Migration

B79. AIRWAY SMOOTH MUSCLE IN ASTHMA | April 30, 2024 | Volume: No volume available | Issue: No issue available | Pages: A4463-A4463

10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4463

Functional Role of Glial Derived Neurotrophic Factor in a Mixed Allergen Murine Model of Asthma

B79. AIRWAY SMOOTH MUSCLE IN ASTHMA | April 30, 2024 | Volume: No volume available | Issue: No issue available | Pages: A4459-A4459

10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4459

Mimecan and a Functional Fragment Hereof as a Novel Regenerative Agent for COPD

A18. FIXING WHAT'S BROKEN: NOVEL THERAPEUTICS FOR LUNG REMODELING | April 30, 2024 | Volume: No volume available | Issue: No issue available | Pages: A1050-A1050

10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a1050

Downregulation of protein phosphatase 2Aα in asthmatic airway smooth muscle

American Journal of Physiology-Lung Cellular and Molecular Physiology | March 26, 2024 | Volume: 326 | Issue: 5 | Pages: L651-L659

10.1152/ajplung.00050.2024 | PMID 38529552

This novel study deciphered the expression and function of protein phosphatase 2Aα (PP2Aα) in airway smooth muscle (ASM) during asthma and/or inflammation. We showed robust expression of PP2Aα in human ASM while its downregulation in asthmatic ASM. Similarly, we demonstrated reduced PP2Aα expression in ASM exposed to proinflammatory cytokines. PP2Aα activation inhibited bronchoconstriction of isolated mouse bronchi. In addition, we unveiled that PP2Aα activation inhibits the intracellular calcium release and myosin light chain phosphorylation in human ASM.