Beirne, Deborah

National Health Service

Citations 2

Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade

Science Translational Medicine | January 3, 2018 | Volume: 10 | Issue: 422 | Pages: No page available

10.1126/scitranslmed.aam7577 | PMID 29298869

Intravenous infusion of oncolytic reovirus in patients leads to infection of brain tumors, infiltration by cytotoxic T cells, and up-regulation of PD-L1.

Cell Carriage, Delivery, and Selective Replication of an Oncolytic Virus in Tumor in Patients

Science Translational Medicine | June 13, 2012 | Volume: 4 | Issue: 138 | Pages: No page available

10.1126/scitranslmed.3003578 | PMID 22700953

Oncolytic reovirus is carried by cells to tumors and protected from neutralizing antibodies in the circulation.