Sabnis, Ram W.

Abstract Provided herein are novel tetrahydropyridinyl-6,6-bicyclic compounds as 5-HT2A receptor agonists, pharmaceutical compositions, use of such compounds in treating depression, anxiety, substance abuse and headaches, and processes for preparing such compounds.

Abstract Provided herein are novel benzofuran derivatives as SARM1 inhibitors, pharmaceutical compositions, use of such compounds in treating axonal degeneration, and processes for preparing such compounds.

Abstract Provided herein are novel compounds as 5-HT2A agonists, pharmaceutical compositions, use of such compounds in treating mental illness or CNS disorders and processes for preparing such compounds.

Abstract Provided herein are novel compounds as orexin 2 receptor agonists, pharmaceutical compositions, use of such compounds in treating narcolepsy, and processes for preparing such compounds.

Abstract Provided herein are novel compounds as TREM2 agonists, pharmaceutical compositions, use of such compounds in treating Parkinson’s disease, Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, Nasu-Hakola disease, and stroke, and processes for preparing such compounds.

Abstract Provided herein are novel 6,5-bicyclic compounds as 5-HT2A receptor agonists, pharmaceutical compositions, use of such compounds in treating depression, anxiety, substance abuse, and headaches, and processes for preparing such compounds.