Compromised pressure-generating capacity of diaphragmatic muscle and its interaction with the lower rib cage at high lung volume during airway occlusion
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology | October 24, 2025 | Volume: 329 | Issue: 6 | Pages: R959-R971
Data from the current study support the hypothesis that the pressure-generating capacity of the diaphragm at high lung volume is compromised primarily due to a mechanism that involves a combined mechanical effect of hyperinflation and substantial muscle contraction rather than a significant loss of its muscle fiber curvature.