Gandhi, Manish J.

ABSTRACT HLA‐DRB1*10:52 is characterised by a single nucleotide substitution in codon 133 in exon 3.

ABSTRACT The HLA‐DQA1*01:205N allele is characterised by a nonsense mutation in codon 114 in exon 3.

ABO incompatibility is frequent in haematopoietic stem cell transplantation (HSCT), yet the clinical impact of non-ABO red blood cell (RBC) alloimmunisation remains less defined. We describe the clinical course of a man in his 50s with chronic eosinophilic leukaemia who underwent a mismatched unrelated donor (MMUD) HSCT. Despite a major ABO mismatch and high-titre pre-existing anti-E antibodies against an E-antigen positive donor, the patient achieved successful trilineage engraftment without haemolysis. Six months after the transplant, he developed severe pancytopenia and a positive direct antiglobulin test (DAT) with anti-E elution. These serologic findings coincided with disease relapse rather than isolated immune-mediated haemolysis. This case illustrates that successful engraftment is possible across RhE-incompatibility and underscores the need to interpret late serologic abnormalities within the broader context of graft function and disease status.

ABSTRACT HLA‐DQA1*01:67:01 is characterised by a single nucleotide substitution in codon 100 in Exon 3.

ABSTRACT HLA‐DPA1*01:49 is characterised by a single nucleotide substitution in codon 119 in exon 3.

ABSTRACT HLA‐B*15:591 is characterised by a single nucleotide substitution in codon 219 in exon 4.

ABSTRACT HLA‐C*01:155 is characterised by a single nucleotide substitution in codon 225 in exon 4.

ABSTRACT The novel HLA‐A*26:268 allele is characterised by a single nucleotide substitution in exon 7.

ABSTRACT The HLA‐DQA1*01:169 allele is characterised by a single nucleotide substitution in codon 175 in exon 3.