This analysis provides a novel assessment of the relationship between the severity of right ventricular dysfunction (RVD) and blood volume expansion (BVE) on clinical outcomes in patients with chronic left-sided heart failure. Findings demonstrate that despite the high prevalence of moderate or greater RVD, persistent BVE was associated with better 1-year event-free survival relative to normal BV. Hypothesis-generating, this suggests that BVE may provide an adaptive response compensating in part for the impact of RVD in chronic HF.