Abstract Hospital medicine (HM), a well‐established clinical specialty, requires clarity of research priorities to identify target areas for investment in HM research infrastructure and activities. The Society of Hospital Medicine's Research Committee developed a 20‐item survey and used purposeful sampling of US hospitalist leaders to prioritize primary research topic domains and subdomains. Respondents were asked to rank their HM research priorities using a scale (1 [highest] to 8 [lowest]). Of 239 surveys distributed, 81 (34%) responded. Respondents were predominantly White (53%) and from academic institutions (57%). “ Overall, 46% of respondents were male and 33% were female. ” Top‐ranked research domains were innovation in care delivery (median 2, IQR 1,3), value‐based care (median 3.5, IQR 2,6), and health disparities (median 4, IQR 2,5). This survey identified top HM research priorities including systems‐based topics and health disparities, aligning with HM's identity as a specialty focused on improving systems of care and inequities in care.