ABSTRACT Pancreatic diseases, including pancreatitis, may be associated with skin manifestations, and prompt recognition is crucial for diagnosis and prognosis. Pancreatic panniculitis is an uncommon dermatologic condition occurring in only 0.3%–3% of pancreatic diseases. Very rarely, the triad of pancreatitis, panniculitis, and polyarthritis syndrome can be observed. Of the scant cases in the literature, most patients received treatment with nonsteroidal anti-inflammatory drugs and/or steroids. To our knowledge, this is the first case to outline an endoscopic approach for pancreatitis, panniculitis, and polyarthritis syndrome in the setting of a pseudocyst.