siRNA delivery to target cellular processes is an appealing area in lung diseases such as asthma. To realize this potential requires efficient, targeted cytosolic delivery without cellular toxicity or siRNA degradation. We demonstrate the efficacy of PONI-Guan nanoparticles in accessing airway epithelial and smooth muscle cells with specific siRNA targeting of mRNAs of interest while maintaining barrier integrity and avoiding cellular toxicity.
Targeting BDNF/arginase Pathways in Airway Remodeling
D30. A NARROW ROAD TO AIRWAY HYPERRESPONSIVENESS | April 30, 2024 | Volume: No volume available | Issue: No issue available | Pages: A7178-A7178