Rationale: Dengue fever is a widespread mosquito-borne viral disease, most prevalent in the tropical and subtropical areas of the world. There has been a significant rise in the incidence and number of outbreaks of dengue in recent years, which has made it a matter of global concern. It may be associated with a number of renal complications, ranging from hematuria, proteinuria, glomerulonephritis, and acute tubular necrosis. However, renal cortical necrosis (RCN) is a rare renal complication of this disease. Patients concerns: We report the case of a young gentleman who presented with fever, vomiting, and anuria. On workup, he was found to be having complicated Dengue fever with RCN resulting in acute renal failure. Diagnosis: To the best of our knowledge, RCN is not a reported renal complication of dengue fever. Interventions and outcomes: Our report highlights the importance of early consideration of renal cortical necrosis in patients with dengue fever and persistent anuria. Lesson: This would allow for better disease prognostication while enabling physicians to develop more effective treatment strategies.