EFFECT OF COLLAGEN CONCENTRATIONS ON THE CONTRACTION AND MATERIAL PROPERTIES OF BONE MARROW STROMAL CELL-SEEDED GEL(3A2 Cellular & Tissue Engineering & Biomaterials II)
The Proceedings of the Asian Pacific Conference on Biomechanics : emerging science and technology in biomechanics | June 19, 2017 | Volume: 2007.3 | Pages: S173
The purpose of this study was to assess tendon metabolism and suture pull-out strength after simple tendon suture in a tissue culture model. One hundred and twelve flexor digitorum profundus tendons from 28 dogs were cultured for 7, 14, or 21 days with or without a static tensile load. In both groups increased levels of matrix metalloproteinase (MMP) mRNA was noted. Suture pull-out strength did not decrease during tissue culture. While the presence of a static load had no effect on the pull-out strength, it did affect MMP mRNA expression. This tissue culture model could be useful in studying the effect of factors on the tendon-suture interface.