AD-linked R47H-
TREM2
mutation induces disease-enhancing microglial states via AKT hyperactivation
Science Translational Medicine | December 1, 2021 | Volume: 13 | Issue: 622 | Pages: No page available
10.1126/scitranslmed.abe3947
| PMID 34851693
R47H- TREM2 mutation enhances AKT signaling in human AD microglia and mediates proinflammatory and synaptic toxicity in a tauopathy mouse model.