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Gakhar, Lokesh

Mayo Clinic

Mayo Clinic in Arizona

Citations 1

Interactions of ubiquitin and CHMP5 with the V domain of HD-PTP reveals role for regulation of Vps4 ATPase

Molecular Biology of the Cell | September 29, 2021 | Volume: 32 | Issue: 22 | Pages: No page available

10.1091/mbc.e21-04-0219 | PMID 34586919

Structural studies reveal that the V domain of HD-PTP has two tandem binding sites for binding ubiquitin. Like its yeast counterpart Bro1, HD-PTP binds the Vps4 MIT domain, stimulating its activity in a manner that is augmented by ubiquitin binding.