Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS
Science Translational Medicine | July 28, 2021 | Volume: 13 | Issue: 604 | Pages: No page available
10.1126/scitranslmed.abe1923
| PMID 34321318
Nuclear accumulation of CHMP7 leads to multiple cellular pathologies that can be mitigated via CHMP7 ASOs in familial and sporadic ALS iPSNs.