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Celnik, Pablo

0000-0002-7953-0551

A5029383812 | I145311948

Mayo Clinic

Johns Hopkins University

Citations 2

Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis

JAMA Neurology | November 23, 2020 | Volume: 78 | Issue: 2 | Pages: 186

10.1001/jamaneurol.2020.4300 | PMID 33226425

Prevalence of Sleep Disturbance in Closed Head Injury Patients in a Rehabilitation Unit

Neurorehabilitation and Neural Repair | July 28, 2008 | Volume: 22 | Issue: 4 | Pages: 341-347

10.1177/1545968308315598 | PMID 18663247

Traumatic brain injury (TBI) is a leading cause of disability in young people in the United States. Disorders of arousal and attention are common in closed head injury (CHI). Daytime drowsiness impairs participation in rehabilitation, whereas nighttime wakefulness leads to falls and behavioral disturbances. Sleep disturbances in TBI reported in the literature have included excessive daytime somnolence, sleep phase cycle disturbance, narcolepsy, and sleep apnea. Although well known to the clinician treating these patients, the extent and prevalence of disrupted sleep in patients in an acute inpatient rehabilitation unit has not been described. Objective. To determine the prevalence of sleep wake cycle disturbance (SWCD) in patients with CHI in a TBI rehabilitation unit. Design. Prospective observational. Setting. Inpatient specialized brain injury rehabilitation unit. Patients. Thirty-one consecutive admissions to a brain injury rehabilitation unit with the diagnosis of CHI. Results. Twenty-one patients (68%) had aberrations of nighttime sleep. There was no significant difference in Glasgow Coma Score on admission to trauma nor was there any significant difference in age between the affected and unaffected groups. Patients with SWCD had longer stays in both the trauma center ( P < .003) and the rehabilitation center ( P < .03). Conclusions. There is a high prevalence of SWCD in CHI patients admitted to a brain injury rehabilitation unit. Patients with SWCD have longer stays in both acute and rehabilitation settings and may be a marker for more severe injury.