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Abraham, Richard

A5003164142 | I79510175

Mayo Clinic

Cardiff University

Citations 6

The Role of Variation at AβPP, PSEN1, PSEN2, and MAPT in Late Onset Alzheimer's Disease

Journal of Alzheimer's Disease | May 16, 2018 | Volume: 28 | Issue: 2 | Pages: 377-387

10.3233/jad-2011-110824 | PMID 22027014

A Multi-Center Study of ACE and the Risk of Late-Onset Alzheimer's Disease

Journal of Alzheimer's Disease | May 16, 2018 | Volume: 24 | Issue: 3 | Pages: 587-597

10.3233/jad-2011-101914 | PMID 21297258

P4‐133: Genome‐wide association study of age at onset of Alzheimer's disease

Alzheimer's & Dementia | June 25, 2009 | Volume: 5 | Issue: 4S_Part_15 | Pages: No page available

10.1016/j.jalz.2009.04.801

P4‐124: An examination of previously reported Alzheimer candidate genes within a large genome‐wide association dataset

Alzheimer's & Dementia | June 25, 2009 | Volume: 5 | Issue: 4S_Part_15 | Pages: No page available

10.1016/j.jalz.2009.04.792

P4‐121: Genome‐wide association study of Alzheimer's with psychotic symptoms

Alzheimer's & Dementia | June 25, 2009 | Volume: 5 | Issue: 4S_Part_15 | Pages: No page available

10.1016/j.jalz.2009.04.789

Susceptibility Locus for Alzheimer's Disease on Chromosome 10

Science | July 27, 2002 | Volume: 290 | Issue: 5500 | Pages: 2304-2305

10.1126/science.290.5500.2304 | PMID 11125144

The apolipoprotein E ( APOE ) gene is the only genetic risk factor that has so far been linked to risk for late-onset Alzheimer's disease (LOAD). However, 50 percent of Alzheimer's disease cases do not carry an APOE4 allele, suggesting that other risk factors must exist. We performed a two-stage genome-wide screen in sibling pairs with LOAD to detect other susceptibility loci. Here we report evidence for an Alzheimer's disease locus on chromosome 10. Our stage one multipoint lod score (logarithm of the odds ratio for linkage/no linkage) of 2.48 (266 sibling pairs) increased to 3.83 in stage 2 (429 sibling pairs) close to D10S1225 (79 centimorgans). This locus modifies risk for Alzheimer's disease independent of APOE genotype.