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Crook, Richard

https://orcid.org/0000-0001-6782-1581

A5079307479 | I4210146710

Mayo Clinic

Mayo Clinic in Florida

Citations 10

Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy

Neurology | May 13, 2012 | Volume: 63 | Issue: 7 | Pages: 1168-1174

10.1212/01.wnl.0000140289.18472.15 | PMID 15477533

An Iranian family with Alzheimer’s disease caused by a novel APP mutation (Thr714Ala)

Neurology | May 13, 2012 | Volume: 58 | Issue: 10 | Pages: 1574-1575

10.1212/wnl.58.10.1574 | PMID 12034808

A kindred with Parkinson’s disease not showing genetic linkage to established loci

Neurology | May 13, 2012 | Volume: 54 | Issue: 2 | Pages: 504-504

10.1212/wnl.54.2.504 | PMID 10668726

Neurodegenerative diseases of Guam: Analysis of TAU

Neurology | May 13, 2012 | Volume: 53 | Issue: 2 | Pages: 411-411

10.1212/wnl.53.2.411 | PMID 10430438

TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers

Neurology | December 22, 2010 | Volume: 76 | Issue: 5 | Pages: 467-474

10.1212/wnl.0b013e31820a0e3b | PMID 21178100

P1‐185: Wild‐type human TDP‐43 induces mitochondrial abnormalities and axonal degeneration in transgenic mice

Alzheimer's & Dementia | July 11, 2010 | Volume: 6 | Issue: 4S_Part_8 | Pages: No page available

10.1016/j.jalz.2010.05.735

P4‐047: Use of a wild‐type tauopathy model to generate a novel Alzheimer model

Alzheimer's & Dementia | June 25, 2009 | Volume: 5 | Issue: 4S_Part_15 | Pages: No page available

10.1016/j.jalz.2009.04.917

P2‐172: Wild‐type mouse tau transgenic model: Halfway to a complete AD model

Alzheimer's & Dementia | July 24, 2008 | Volume: 4 | Issue: 4S_Part_12 | Pages: No page available

10.1016/j.jalz.2008.05.1246

P3–163: Identification of a novel risk gene for progressive supranuclear palsy by a genome–wide scan of 500,288 SNPs

Alzheimer's & Dementia | August 17, 2006 | Volume: 2 | Issue: 3S_Part_14 | Pages: No page available

10.1016/j.jalz.2006.05.1431

Susceptibility Locus for Alzheimer's Disease on Chromosome 10

Science | July 27, 2002 | Volume: 290 | Issue: 5500 | Pages: 2304-2305

10.1126/science.290.5500.2304 | PMID 11125144

The apolipoprotein E ( APOE ) gene is the only genetic risk factor that has so far been linked to risk for late-onset Alzheimer's disease (LOAD). However, 50 percent of Alzheimer's disease cases do not carry an APOE4 allele, suggesting that other risk factors must exist. We performed a two-stage genome-wide screen in sibling pairs with LOAD to detect other susceptibility loci. Here we report evidence for an Alzheimer's disease locus on chromosome 10. Our stage one multipoint lod score (logarithm of the odds ratio for linkage/no linkage) of 2.48 (266 sibling pairs) increased to 3.83 in stage 2 (429 sibling pairs) close to D10S1225 (79 centimorgans). This locus modifies risk for Alzheimer's disease independent of APOE genotype.