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Lu, Lichun

https://orcid.org/0000-0002-3862-6493

A5102009520 | I1330342723

Mayo Clinic

Mayo Clinic

Citations 78

Characterization of Photo-Cross-Linked Oligo[poly(ethylene glycol) fumarate] Hydrogels for Cartilage Tissue Engineering

Biomacromolecules | April 10, 2007 | Volume: 8 | Issue: 5 | Pages: 1702-1709

10.1021/bm070052h | PMID 17419584

Poly(propylene fumarate) Bone Tissue Engineering Scaffold Fabrication Using Stereolithography:  Effects of Resin Formulations and Laser Parameters

Biomacromolecules | February 28, 2007 | Volume: 8 | Issue: 4 | Pages: 1077-1084

10.1021/bm060834v | PMID 17326677

Fabrication and Characterization of Poly(Propylene Fumarate) Scaffolds with Controlled Pore Structures Using 3-Dimensional Printing and Injection Molding

Tissue Engineering | October 20, 2006 | Volume: 12 | Issue: 10 | Pages: 2801-2811

10.1089/ten.2006.12.2801 | PMID 17518649

Bone-Tissue-Engineering Material Poly(propylene fumarate):  Correlation between Molecular Weight, Chain Dimensions, and Physical Properties

Biomacromolecules | June 10, 2006 | Volume: 7 | Issue: 6 | Pages: 1976-1982

10.1021/bm060096a | PMID 16768422

Effects of Dynamic Fluid Pressure on Chondrocytes Cultured in Biodegradable Poly(glycolic acid) Fibrous Scaffolds

Tissue Engineering | January 13, 2006 | Volume: 11 | Issue: 11-12 | Pages: 1852-1859

10.1089/ten.2005.11.1852 | PMID 16411831

Synthesis, Material Properties, and Biocompatibility of a Novel Self-Cross-Linkable Poly(caprolactone fumarate) as an Injectable Tissue Engineering Scaffold

Biomacromolecules | September 12, 2005 | Volume: 6 | Issue: 5 | Pages: 2503-2511

10.1021/bm050206y | PMID 16153086

A Biodegradable and Cross-Linkable Multiblock Copolymer Consisting of Poly(propylene fumarate) and Poly(ε-caprolactone):  Synthesis, Characterization, and Physical Properties

Macromolecules | August 16, 2005 | Volume: 38 | Issue: 17 | Pages: 7358-7370

10.1021/ma050884c

Biological Activity of rhBMP-2 Released From PLGA Microspheres

Journal of Biomechanical Engineering | July 27, 2002 | Volume: 122 | Issue: 3 | Pages: 289-292

10.1115/1.429662 | PMID 10923299

Human recombinant bone morphogenetic protein-2 (rhBMP-2) has been proven effective in stimulating the regeneration of bone in both skeletal and extraskeletal locations. Through encapsulation within, and release from, biodegradable poly(DL-lactic-co-glycolic acid) (PLGA) microspheres, a proven vehicle for sustained delivery of various proteins, the local concentrations of rhBMP-2 could be maintained at optimal levels to stimulate bone regeneration and remodeling at the site of healing in diverse clinical settings. Thus the purpose of this work was to investigate the encapsulation of rhBMP-2 in PLGA microspheres and its biologic activity upon release. Using in vitro tests in simulated body fluids, the effect of rhBMP-2 released from PLGA microspheres upon osteoblast cell cultures was found to be statistically similar to the effect produced by positive controls consisting of nonencapsulated aqueous rhBMP-2 in simulated body fluids. This clarifies an important step in skeletal tissue engineering strategies aimed at the use of encapsulated rhBMP-2 to stimulate bone regeneration and remodeling. [S0148-0731(00)01303-0]