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Jessell, Thomas M.

A5112062141 | I136199984

Mayo Clinic

Harvard University

Citations 1

Intrathecal Capsaicin Depletes Substance P in the Rat Spinal Cord and Produces Prolonged Thermal Analgesia

Science | October 5, 2006 | Volume: 206 | Issue: 4417 | Pages: 481-483

10.1126/science.228392 | PMID 228392

A single intrathecal injection of capsaicin depletes substance P from primary sensory neurons and causes a prolonged increase in the thermal and chemical pain thresholds of the rat but no apparent change in responses to noxious mechanical stimuli.