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TGF-β inhibitors stimulate red blood cell production by enhancing self-renewal of BFU-E erythroid progenitors
Gao, Xiaofei , Lee, Hsiang‐Ying , Rocha, Edroaldo Lummertz da , Zhang, Cheng , Lu, Yi-Fen , Feng, Yuxiong , Ezike, Jideofor , Elmes, Russell R., Barrasa, M. Inmaculada , Cahan, Patrick , Hu, Li , Daley, George Q. , Lodish, Harvey F. , da Rocha, Edroaldo Lummertz, Li, Dandan , Zhang, Cheng

Blood | October 24, 2016 | Volume: 128 | Issue: 23 | Pages: 2637-2641

10.1182/blood-2016-05-718320 | PMID 27777239 Get It

Key Points The type III TGF-β receptor is a marker that distinguishes “early” and “late” BFU-Es. TGF-β inhibitors increase early BFU-E cell self-renewal and total erythroblast production.