Mayo Clinic - AuthorCitation

Association of Apolipoprotein E ɛ4, Educational Level, and Sex With Tau Deposition and Tau-Mediated Metabolic Dysfunction in Older Adults

Castillo, Anna , Graff‐Radford, Jonathan , Lowe, Val J. , Petersen, Ronald C. , Jack, Clifford R. , Vemuri, Prashanthi , Castillo, Anna M, Jack, Clifford R , Vemuri, Prashanthi , Castillo, Anna M , Ramanan, Vijay K. , Knopman, David S. , Mielke, Michelle M.

JAMA Network Open | October 23, 2019 | Volume: 2 | Issue: 10 | Pages: e1913909

10.1001/jamanetworkopen.2019.13909 | PMID 31642932

Practical algorithms for amyloid β probability in subjective or mild cognitive impairment

Maserejian, Nancy N., Bian, Shijia , Jaeger, Judith , Syrjanen, Jeremy A. , Aakre, Jeremiah A. , Jack, Clifford R. , Aakre, Jeremiah, Jack, Clifford R , Wang, Wenting , Mielke, Michelle M. , Gao, Feng

Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring | October 21, 2019 | Volume: 11 | Issue: 1 | Pages: 710-720

10.1016/j.dadm.2019.09.001 | PMID 31700988

AbstractIntroductionPractical algorithms predicting the probability of amyloid pathology among patients with subjective cognitive decline or mild cognitive impairment may help clinical decisions regarding confirmatory biomarker testing for Alzheimer's disease.MethodsAlgorithm feature selection was conducted with Alzheimer's Disease Neuroimaging Initiative and Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing data. Probability algorithms were developed in Alzheimer's Disease Neuroimaging Initiative using nested cross‐validation accompanied by stratified subsampling to obtain 1000 internally validated decision trees. Semi‐independent validation was conducted using Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing. Independent external validation was conducted in the population‐based Mayo Clinic Study of Aging.ResultsTwo algorithms were developed using age and normalized immediate recall z‐scores, with or without apolipoprotein E ε4 carrier status. Both algorithms had robust performance across data sets and when substituting different recall memory tests.DiscussionThe statistical framework resulted in robust probability estimation. Application of these algorithms may assist in clinical decision‐making for further testing to diagnose amyloid pathology.

P3‐432: CEREBRAL AMYLOID ANGIOPATHY IS MORE SEVERE IN AUTOSOMAL DOMINANT AD CASES WITH CEREBRAL MICROHEMORRHAGES: RESULTS FROM THE DIAN STUDY

Perrin, Richard J. , Cairns, Nigel J. , Franklin, Erin , Xiong, Chengjie , Preboske, Gregory M., (DIAN), Dominantly Inherited Alzheimer Network, Joseph‐Mathurin, Nelly , Jack, Clifford R. , Morris, John C. , Bateman, Randall J. , Benzinger, Tammie L.S. , (DIAN), Dominantly Inherited Alzheimer Network

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_21 | Pages: No page available

10.1016/j.jalz.2019.06.5068

P4‐537: DETECTION OF ALZHEIMER'S DISEASE IN CSF USING AUTOMATED ASSAYS FOR CLASSICAL CSF BIOMARKERS

Wiste, Heather J. , Weigand, Stephen D. , Eichenlaub, Udo, Batrla‐Utermann, Richard, Dyer, Roy B. , Algeciras‐Schimnic, Alicia, Petersen, Ronald C. , Harten, Argonde C. van , Mielke, Michelle M. , Kremers, Walter K. , Knopman, David S. , Jack, Clifford R.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_29 | Pages: No page available

10.1016/j.jalz.2019.08.084

DT‐02‐01: REPURPOSING FDG‐PET AS A DIAGNOSTIC TOOL FOR ALZHEIMER'S‐RELATED TDP‐43‐PROTEINOPATHY

Petersen, Ronald C. , Petrucelli, Leonard , Lowe, Val J. , Whitwell, Jennifer L. , Josephs, Keith A. , Buciuc, Marina , Botha, Hugo , Murray, Melissa E. , Jones, David T. , Knopman, David S. , Boeve, Bradley F. , Jack, Clifford R. , Dickson, Dennis W.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_28 | Pages: No page available

10.1016/j.jalz.2019.08.010

IC‐P‐099: SUBJECT FACTORS RELATED TO CSF DYNAMICS CONFOUND MEASUREMENT OF CSF BIOMARKERS IN ADNI

Townley, Ryan , Gunter, Jeffrey L. , Wiste, Heather J. , Graff‐Radford, Jonathan , Senjem, Matthew L. , Jack, Clifford R. , Jones, David T.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_2 | Pages: No page available

10.1016/j.jalz.2019.06.4942

IC‐P‐086: CORTICAL ATROPHY PATTERNS OF EMPIRICALLY DERIVED INCIDENT MCI SUBTYPES IN THE MAYO CLINIC STUDY OF AGING

Albertson, Sabrina M., Spychalla, Anthony J., Bondi, Mark W. , Petersen, Ronald C. , Machulda, Mary M. , Lundt, Emily S. , Mielke, Michelle M. , Jack, Clifford R. , Kremers, Walter K. , Vemuri, Prashanthi , Knopman, David S.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_2 | Pages: No page available

10.1016/j.jalz.2019.06.4929

IC‐P‐078: ALTERED CSF DYNAMICS INFLUENCE DISCREPANCIES BETWEEN CSF AND PET BIOMARKERS OF AMYLOID

Gunter, Jeffrey L. , Townley, Ryan , Wiste, Heather J. , Graff‐Radford, Neill R. , Graff‐Radford, Jonathan , Senjem, Matthew L. , Jack, Clifford R. , Jones, David T.

Alzheimer's & Dementia | October 18, 2019 | Volume: 15 | Issue: 7S_Part_1 | Pages: No page available

10.1016/j.jalz.2019.06.4921

IC‐P‐059: APOE AND EDUCATION: EFFECTS ON REGIONAL TAU AND FDG METABOLISM IN OLDER ADULTS

Graff‐Radford, Jonathan , Lowe, Val J. , Petersen, Ronald C. , Ramanan, Vijay K. , Castillo, Anna , Knopman, David S. , Mielke, Michelle M. , Jack, Clifford R. , Vemuri, Prashanthi