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3043 citation(s) found for "Ha, Patrick K".

Autoimmune paraneoplastic cerebellar degeneration
Truh, Lois I., Lennon, Vanda A. , Rodriguez, Moses , O’Neill, Brian Patrick

Neurology | May 13, 2012 | Volume: 38 | Issue: 9 | Pages: 1380-1380

10.1212/wnl.38.9.1380 | PMID 3045692 Get It

Computer‐assisted stereotaxic biopsy for the diagnosis of primary central nervous system lymphoma
Earle, John D., Scheithauer, B. W., Banks, Peter M. , O’Neill, Brian Patrick , Kelly, Patrick D.

Neurology | May 13, 2012 | Volume: 37 | Issue: 7 | Pages: 1160-1160

10.1212/wnl.37.7.1160 | PMID 3299144 Get It

Familial spastic paraparesis
Swanson, Jerry W., Brown, Frank R., Griffin, John W., Moser, Hugo W., O’Neill, Brian Patrick

Neurology | May 13, 2012 | Volume: 35 | Issue: 8 | Pages: 1233-1233

10.1212/wnl.35.8.1233 | PMID 4022363 Get It

Adrenoleukodystrophy
Moser, Hugo W., Saxena, Krishna M., Marmion, Lee C., O’Neill, Brian Patrick

Neurology | May 13, 2012 | Volume: 34 | Issue: 6 | Pages: 798-798

10.1212/wnl.34.6.798 | PMID 6539445 Get It

Adrenoleuko‐dystrophy (ALD)
Marler, John R., Forbes, Glenn S. , Moser, Hugo W., O’Neill, Brian Patrick

Neurology | May 13, 2012 | Volume: 33 | Issue: 9 | Pages: 1203-1203

10.1212/wnl.33.9.1203 | PMID 6684256 Get It

Adrenoleukodystrophy an X‐linked disorder
O’Neill, Brian Patrick

Neurology | May 13, 2012 | Volume: 33 | Issue: 7 | Pages: 959

10.1212/wnl.33.7.959-a Get It

Familial X‐linked Addison disease as an expression of adrenoleukodystrophy (ALD)
Moser, Hugo W., Saxena, Krishna M., O’Neill, Brian Patrick

Neurology | May 13, 2012 | Volume: 32 | Issue: 5 | Pages: 543-543

10.1212/wnl.32.5.543 | PMID 6280107 Get It

Adrenoleukodystrophy
Moser, Hugo W., Marmion, Lee C., O’Neill, Brian Patrick

Neurology | May 13, 2012 | Volume: 32 | Issue: 5 | Pages: 540-540

10.1212/wnl.32.5.540 | PMID 6280106 Get It

The adrenoleukomyeloneuropathy complex
Mannion, L. C., Feringa, E. R., O’Neill, Brian Patrick

Neurology | May 13, 2012 | Volume: 31 | Issue: 2 | Pages: 151-151

10.1212/wnl.31.2.151 | PMID 6258103 Get It

Clonal competition with alternating dominance in multiple myeloma
Keats, Jonathan J. , Chesi, Marta , Egan, Jan B. , Garbitt, Victoria M. , Braggio, Esteban , Wier, Scott Van, Blackburn, Patrick R. , Baker, Angela , Dispenzieri, Angela , Kumar, Shaji , Rajkumar, S. Vincent , Carpten, John D. , Barrett, Michael T. , Fonseca, Rafaël , Stewart, A. Keith, Bergsagel, P. Leif , Palmer, Stephen E , Bergsagel, P. Leif , Rajkumar, S Vincent , Dispenzieri, Angela , Braggio, Esteban , Keats, Jonathan J , Fonseca, Rafael

Blood | April 13, 2012 | Volume: 120 | Issue: 5 | Pages: 1067-1076

10.1182/blood-2012-01-405985 | PMID 22498740 Get It

Abstract Emerging evidence indicates that tumors can follow several evolutionary paths over a patient's disease course. With the use of serial genomic analysis of samples collected at different points during the disease course of 28 patients with multiple myeloma, we found that the genomes of standard-risk patients show few changes over time, whereas those of cytogenetically high-risk patients show significantly more changes over time. The results indicate the existence of 3 temporal tumor types, which can either be genetically stable, linearly evolving, or heterogeneous clonal mixtures with shifting predominant clones. A detailed analysis of one high-risk patient sampled at 7 time points over the entire disease course identified 2 competing subclones that alternate in a back and forth manner for dominance with therapy until one clone underwent a dramatic linear evolution. With the use of the Vk*MYC genetically engineered mouse model of myeloma we modeled this competition between subclones for predominance occurring spontaneously and with therapeutic selection.