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Pabelick, C.M.

Mayo Clinic

Mayo Clinic

Citations 40

Receptor Specific Estrogen Signaling Regulates Extracellular Matrix Deposition in Human Airway Smooth Muscle Remodeling
Kalidhindi, R.S.R., Pabelick, C.M., Ambhore, Nilesh Sudhakar , Prakash, Y. S. , Sathish, Venkatachalem

A63. PATHOPHYSIOLOGY OF ASTHMA IN CELLS, TISSUES, AND ANIMAL MODELS | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A2189-A2189

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2189 Get It

Hyperoxia-Induced Soluble Guanylyl Cyclase (sGC) Dysfunction in Developing Airway Involves the Calcium Sensing Receptor (CaSR)
Ravix, Jovanka, Britt, Rodney D. , Roesler, A.M., Manlove, L., Thompson, Marita, Pabelick, C.M., Wicher, Sarah A. , Thompson, M., Prakash, Y. S.

A63. PATHOPHYSIOLOGY OF ASTHMA IN CELLS, TISSUES, AND ANIMAL MODELS | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A2180-A2180

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2180 Get It

Proteostasis and Senescence in the Aging Lung
Roesler, A.M., Manlove, L., Roos, B., Pabelick, C.M., Wicher, Sarah A. , Prakash, Y. S.

A63. PATHOPHYSIOLOGY OF ASTHMA IN CELLS, TISSUES, AND ANIMAL MODELS | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A2178-A2178

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2178 Get It

Kisspeptins Expression and Function in Asthmatic Human Airway Smooth Muscle
Borkar, Niyati A. , Kalidhindi, R.S.R., Ambhore, Nilesh Sudhakar , Loganathan, Jagadish , Pabelick, C.M., Prakash, Y. S. , Sathish, Venkatachalem

A63. PATHOPHYSIOLOGY OF ASTHMA IN CELLS, TISSUES, AND ANIMAL MODELS | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A2174-A2174

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2174 Get It

Calcium-Sensing Receptor Contributes to Hyperoxia-Induced Enhancement of Calcium Regulation and Remodeling in Human Fetal Airway Smooth Muscle
Roesler, A.M., Pabelick, C.M., MacFarlane, Peter M. , Martin, Richard J. , Prakash, Y. S.

A63. PATHOPHYSIOLOGY OF ASTHMA IN CELLS, TISSUES, AND ANIMAL MODELS | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A2169-A2169

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2169 Get It

Effect of Stretch on Hyaluronan Expression and Signaling in Developing Human Airway Smooth Muscle
Teske, Jacob J. , Manlove, L., Orakwue, A., Roesler, A.M., MacFarlane, Peter M. , Pabelick, C.M., Teske, Jacob J , Prakash, Y. S.

A63. PATHOPHYSIOLOGY OF ASTHMA IN CELLS, TISSUES, AND ANIMAL MODELS | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A2162-A2162

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2162 Get It

Thymic Stromal Lymphopoietin Role in Human Pulmonary Artery Smooth Muscle Proliferation and Contractility
Roos, B., Thompson, Marita, Venkatachalem, S., Manlove, L., Miller, Jean‐Philippe , Pabelick, C.M., Thompson, M., Venkatachalem, S., Prakash, Y. S.

C71. PULMONARY HYPERTENSION | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A5498-A5498

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5498 Get It

Moderate Hyperoxia Induces Senescence in Human Fetal Lung Fibroblasts
You, Kai , Parikh, Pavan , Khandalavala, Karl, Yang, Bangyuan , Roesler, A.M., Manlove, L., Roos, B., Pabelick, C.M., Wicher, Sarah A. , Prakash, Y. S.

C70. NEONATAL AND PEDIATRIC LUNG DISEASE | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A5494-A5494

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a5494 Get It

Dexamethasone Reduces Effects of Brain-Derived Neurotrophic Factor on Human Airway Smooth Muscle
Britt, Rodney D. , Thompson, Martin W., Yang, Bo , Sasse, Sarah K., Pabelick, C.M., Thompson, M., Wicher, Sarah A. , Yang, B., Gerber, Anthony N. , Prakash, Y. S.

C19. NEW PATHWAYS REGULATING AIRWAY SMOOTH MUSCLE CONTRACTION: POTENTIAL TARGETS FOR ASTHMA THERAPY | August 26, 2019 | Volume: No volume available | Issue: No issue available | Pages: A4286-A4286

10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4286 Get It

Muscarinic receptor stimulation modulates the effect of halothane on Mn2+ influx in airway smooth muscle
Warner, D. O., Jones, K. A. , Lorenz, Robert R. , Pabelick, C.M.

American Journal of Physiology-Cell Physiology | December 24, 2017 | Volume: 273 | Issue: 3 | Pages: C868-C873

10.1152/ajpcell.1997.273.3.c868 Get It

Prior studies suggest that the mechanism of action by which halothane relaxes airway smooth muscle depends on the contractile state of the cell. We hypothesized that halothane would inhibit the influx of Ca2+ into canine airway smooth muscle cells during submaximal, but not maximal, muscarinic stimulation. This hypothesis was tested by using the rate of quenching of fura 2 fluorescence by Mn2+ in strips of canine tracheal smooth muscle as an index of Ca2+ influx. Acetylcholine (ACh) produced a dose-dependent increase in Mn2+ influx. Halothane (0.64 +/- 0.05 microM) significantly decreased Mn2+ influx and intracellular Ca2+ concentration when added to strips stimulated with a submaximal concentration of ACh (0.3 microM) but had no effect on Mn2+ influx or intracellular Ca2+ concentration during maximal stimulation with ACh (100 microM). Similar results were observed when the strips were treated with verapamil. These results demonstrate that anesthetic effects on Ca2+ homeostasis in intact canine tracheal smooth muscle cells may be critically modulated by receptor-linked mechanisms.