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Moynagh, Michael R.

Mayo Clinic

Mayo Clinic

Citations 14

Decreased Skeletal Muscle Mass is Associated with an Increased Risk of Mortality after Radical Nephrectomy for Localized Renal Cell Cancer
Psutka, Sarah P. , Boorjian, Stephen A. , Moynagh, Michael R., Schmit, Grant D. , Costello, Brian A. , Thompson, R. Houston, Stewart‐Merrill, Suzanne B., Lohse, Christine M. , Cheville, John C. , Leibovich, Bradley C. , Tollefson, Matthew K. , Psutka, Sarah P

Journal of Urology | August 18, 2015 | Volume: 195 | Issue: 2 | Pages: 270-276

10.1016/j.juro.2015.08.072 Get It

Mortality after Radical Cystectomy: Impact of Obesity Versus Adiposity after Adjusting for Skeletal Muscle Wasting
Psutka, Sarah P. , Boorjian, Stephen A. , Moynagh, Michael R., Schmit, Grant D. , Frank, Igor, Carrasco, Alonso , Stewart, Suzanne, Tarrell, Robert F., Thapa, Prabin , Tollefson, Matthew K. , Stewart, Suzanne B, Tarrell, Robert, Psutka, Sarah P

Journal of Urology | November 22, 2014 | Volume: 193 | Issue: 5 | Pages: 1507-1513

10.1016/j.juro.2014.11.088 Get It

Re: Sarcopenia as a Predictor of Complications and Survival Following Radical Cystectomy
Psutka, Sarah P. , Moynagh, Michael R., Schmit, Grant D. , Tollefson, Matthew K. , Moynagh, Michael, Schmit, Grant, Psutka, Sarah P

Journal of Urology | August 8, 2014 | Volume: 192 | Issue: 5 | Pages: 1582-1583

10.1016/j.juro.2014.05.104 Get It

Sarcopenia in patients with bladder cancer undergoing radical cystectomy: Impact on cancer‐specific and all‐cause mortality
Psutka, Sarah P. , Carrasco, Alonso , Schmit, Grant D. , Moynagh, Michael R., Boorjian, Stephen A. , Frank, Igor, Stewart, Suzanne, Thapa, Prabin , Tarrell, Robert F., Cheville, John C. , Tollefson, Matthew K. , Psutka, Sarah P

Cancer | May 19, 2014 | Volume: 120 | Issue: 18 | Pages: 2910-2918

10.1002/cncr.28798 Get It

BACKGROUNDThe authors evaluated sarcopenia as a predictor of cancer‐specific survival (CSS) and overall survival (OS) among patients with urothelial cancer of the bladder undergoing radical cystectomy (RC).METHODSThe lumbar skeletal muscle index (SMI) of 205 patients treated with RC for urothelial cancer between 2000 and 2007 was measured. Sarcopenia was classified according to international consensus definitions (SMI of < 55 cm2/m2 for men and < 39 cm2/m2 for women). The CSS and OS were estimated using the Kaplan‐Meier method and compared with the log‐rank test. Variables associated with CSS and all‐cause mortality were summarized with hazard ratios (HRs).RESULTSOf 205 patients, 141 (68.8%) were sarcopenic. Patients with sarcopenia were older, but were otherwise similar to patients without sarcopenia with respect to sex, Charlson comorbidity index, American Society of Anesthesiologists score, Eastern Cooperative Oncology Group performance status, receipt of neoadjuvant chemotherapy, TNM stage of disease, and tumor grade (P > .05 for all). The median follow‐up was 6.7 years, during which time 135 patients died, including 91 who died of bladder cancer. Sarcopenic patients had significantly worse 5‐year CSS (49% vs 72%; P = .003) and OS (39% vs 70%; P = .003) compared with patients without sarcopenia. Moreover, sarcopenia was found to be independently associated with both increased CSS (HR, 2.14; P = .007) and all‐cause mortality (HR, 1.93; P = .004) on multivariable analysis.CONCLUSIONSThe presence of sarcopenia was found to significantly increase a patient's risk of CSS and all‐cause mortality after undergoing RC for bladder cancer. Cancer 2014;120:2910–2918. © 2014 American Cancer Society.