Norgan, Andrew P
Mayo Clinic
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, US.
Citations 22
An Immunocompromised Child with Bloodstream Infection Caused by Two Escherichia coli Strains, One Harboring NDM-5 and the Other Harboring OXA-48-Like Carbapenemase
Hasassri, M. Earth , Boyce, Thomas G. , Norgan, Andrew P. , Cunningham, Scott A. , Jeraldo, Patricio , Patel, Robin , Banerjee, Ritu , Pogue, Jason M. , Kaye, Keith S. , Jeraldo, Patricio R , Weissman, Scott J. , Patel, Robin , Norgan, Andrew P , Cunningham, Scott A
Antimicrobial Agents and Chemotherapy | May 24, 2016 | Volume: 60 | Issue: 6 | Pages: 3270-3275
ABSTRACT We describe a 16-year-old neutropenic patient from the Middle East with bloodstream infection caused by two carbapenemase-producing Escherichia coli isolates that we characterized by whole-genome sequencing. While one displayed meropenem resistance and was bla NDM positive, the other demonstrated meropenem susceptibility yet harbored bla OXA181 (which encodes a bla OXA48 -like enzyme). This report highlights the challenge of laboratory detection of bla OXA48 -like enzymes and the clinical implications of genotypic resistance detection in carbapenemase-producing Enterobacteriaceae .
Carbapenem- and Colistin-Resistant Enterobacter cloacae from Delta, Colorado, in 2015
Norgan, Andrew P. , Freese, Jarred M., Tuin, Patricia M., Cunningham, Scott A. , Jeraldo, Patricio , Patel, Robin , Jeraldo, Patricio R , Patel, Robin , Norgan, Andrew P , Cunningham, Scott A
Antimicrobial Agents and Chemotherapy | February 17, 2016 | Volume: 60 | Issue: 5 | Pages: 3141-3144
ABSTRACT Resistance to carbapenems in Enterobacteriaceae is a clinical problem of growing significance. Difficulty in treating multidrug-resistant Gram-negative organisms with conventional antibiotics has led to a renewed and increasing use of polymyxin compounds, such as colistin. Here, we report the isolation of carbapenem- and colistin-resistant Enterobacter cloacae from a polymicrobial lower extremity wound in an ambulatory patient. Whole-genome sequencing demonstrated the presence of chromosomal bla IMI-1 and bla AmpC , as well as numerous efflux pump genes.