Citations 11
ADAM-17: A Target to Increase Chemotherapeutic Efficacy in Colorectal Cancer?
Diasio, Robert B. , Lee, Adam M.
Clinical Cancer Research | June 23, 2010 | Volume: 16 | Issue: 13 | Pages: 3319-3321
Abstract Chemotherapy-induced activation of ADAM-17 results in increased growth factor shedding and activation of growth factor receptor-mediated pro-survival response. Enhanced ADAM-17 activity and HER ligand shedding results in resistance to chemotherapy in CRC. Therapies that decrease ADAM-17 activity in conjunction with current treatments may enhance response rates in advanced CRC patients. Clin Cancer Res; 16(13); 3319–21. ©2010 AACR.