Citations 13
CHK2-FOXK axis promotes transcriptional control of autophagy programs
Chen, Yuping , Wu, Jinhuan , Liang, Guang, Geng, Guohe, Zhao, Fei, Yin, Ping, Nowsheen, Somaira , Wu, Chengming , Li, Lei , Kim, Wootae , Zhou, Qin, Huang, Jinzhou , Liu, Jiaqi, Zhang, Chao, Guo, Guijie , Deng, Min , Tu, Xinyi , Liu, Zhongmin , Chen, Yihan , Luo, Kuntian, Yuan, Jian , Li, Yunhui , Li, Lei , Gao, Xiumei , Liu, Zhongmin , Chen, Yihan , Yuan, Jian , Kim, Wootae , Liang, Guang , Wu, Chengming, Lou, Zhenkun , Guo, Guijie
Science Advances | January 1, 2020 | Volume: 6 | Issue: 1 | Pages: No page available
We clarify that DNA damage triggers autophagy by CHK2-FOXK axis, and misregulation of this pathway leads to chemoresistance.
Chk1 inhibitor SCH 900776 enhances the antitumor activity of MLN4924 on pancreatic cancer
Li, Jian-ang, Rong, Yefei , Kuang, Tiantao , Wang, Dansong , Xu, Xuefeng , Yuan, Jian , Luo, Kuntian, Qin, Bo , Nowsheen, Somaira , Lou, Wenhui , Yuan, Jian , Nowsheen, Somaira , Song, Chao , Lou, Zhenkun , Lou, Wenhui
Cell Cycle | November 21, 2017 | Volume: 17 | Issue: 2 | Pages: 191-199
MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks
Wu, Liming , Luo, Kuntian, Lou, Zhenkun , Chen, Junjie
Proceedings of the National Academy of Sciences | August 4, 2008 | Volume: 105 | Issue: 32 | Pages: 11200-11205
The product of the Nijmegen breakage syndrome gene (NBS1) plays crucial roles in DNA damage response through its association with many proteins, including MRE11 and RAD50. However, it remains to be determined exactly how NBS1 accumulates at or near DNA double-strand breaks. Here we report that MDC1 directly binds to NBS1 and targets NBS1 to the sites of DNA damage. The MDC1–NBS1 interaction occurs through a specific region (residues 200–420) of MDC1, which contains multiple consensus casein kinase 2 (CK2) phosphorylation sites. In addition, this interaction requires both the forkhead-associated (FHA) and tandem BRCA1 C-terminal (BRCT) domains of NBS1. Disruption of the MDC1–NBS1 interaction results in failure of NBS1 accumulation at DNA double-strand breaks and impairment of intra-S checkpoint activation. These studies provide important mechanistic insights as to how MDC1 regulates NBS1 and the intra-S-phase checkpoint in response to DNA damage.