Citations 13
Life-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children
Halasa, Natasha , Young, Cameron C. , Newhams, Margaret M. , Nakamura, Mari , Levy, Emily R. , Soma, Vijaya L, Talj, Rana, Fitzgerald, Julie C. , Mack, Elizabeth H. , Schuster, Jennifer E. , Coates, Bria M. , Hall, Mark W. , Schwarz, Adam J. , Kong, Michele, Spinella, Philip C. , Loftis, Laura L. , McLaughlin, Gwenn E., Rowan, Courtney M. , Nofziger, Ryan A. , Babbitt, Christopher , Bowens, Cindy , Flori, Heidi R. , Gertz, Shira J. , Zinter, Matt S. , Hume, Janet R. , Singh, Aalok R. , Crandall, Hillary A, Cullimore, Melissa L. , Patel, Manish M. , Randolph, Adrienne G. , Influenza, for the Pediatric Intensive Care, Investigators, Overcoming COVID-19, Kong, Michele, Gaspers, Mary Glas , Sanders, Ronald C., Irby, Katherine , Peter, Mourani, Harvey, Helen , Osborne, Christina , Sara, Shankman, Mourani, Peter M. , Port, Emily, Van, Kevin A, Carroll, Christopher L. , Tarquinio, Keiko M. , Coates, Bria M, Wellnitz, Kari , Bhoojhawon, Guru , Sullivan, Janice E, Bradford, Tamara T. , Riggs, Becky J. , Randolph, Adrienne G, Chen, Sabrina R., Carroll, Ryan W. , Yager, Phoebe H. , Heidemann, Sabrina M. , Hume, Janet R, Martin, Lora , Malloch, Lacy , Inagaki, Kengo , Schuster, Jennifer E, Kietzman, Abigail , Clouser, Katharine N. , Kleinman, Lawrence C. , Horwitz, Steven M. , Keenaghan, Michael , Doymaz, Sule , Walker, Tracie C. , Hall, Mark W, Lansell, Amanda , Staat, Mary Allen , Carcillo, Joseph A. , Smallcomb, Laura , Halasa, Natasha B, Stewart, Laura S , Romero, Yesenia, Hayek, Haya , Bowens, Cindy, Maamari, Mia , Crandall, Hillary , Smith, Lincoln , Kong, Michele , Young, Cameron C , Randolph, Adrienne G , Levy, Emily R , Spinella, Philip C , Kong, Michele , Hume, Janet R , Staat, Mary A , Gertz, Shira J , Spieker, Andrew J. , Olson, Samantha M. , Amarin, Justin Z. , Moffitt, Kristin , Weiss, Scott L. , Maddux, Aline B. , Schwartz, Stephanie P. , Kong, Michele, Hobbs, Charlotte V. , Bembea, Melania M. , Giuliano, John S. , Cvijanovich, Natalie Z , Thomas, Neal J. , Influenza, for the Pediatric Intensive Care, Investigators, Overcoming COVID-19, Kong, Michele, Typpo, Katri , Michelson, Kelly Nicole , Coates, Bria M, Sullivan, Janice E, Montgomery, Vicki , Havlin, Kevin , Randolph, Adrienne G, Fernandes, Neil D. , Hume, Janet R, Dhanrajani, Anita D. , Schuster, Jennifer E, Hill, Shannon, McCulloh, Russell J. , Li, Simon , Ratner, Adam J. , Dapul, Heda , Harwayne‐Gidansky, Ilana , Hymes, Saul , Hall, Mark W, Shein, Steven L. , Fink, Ericka L. , Halasa, Natasha B, Muñoz, Álvaro Coronado , Bowens, Cindy, McGuire, John K.
Clinical Infectious Diseases | June 19, 2022 | Volume: 76 | Issue: 3 | Pages: e280-e290
Abstract Background Clinical differences between critical illness from influenza infection vs coronavirus disease 2019 (COVID-19) have not been well characterized in pediatric patients. Methods We compared demographics, clinical characteristics, and outcomes of US children (aged 8 months to 17 years) admitted to the intensive care or high-acuity unit with influenza or COVID-19. Using mixed-effects models, we assessed the odds of death or requiring life support for influenza vs COVID-19 after adjustment for age, sex, race and Hispanic origin, and underlying conditions including obesity. Results Children with influenza (n = 179) were younger than those with COVID-19 (n = 381; median, 5.2 years vs 13.8 years), less likely to be non-Hispanic Black (14.5% vs 27.6%) or Hispanic (24.0% vs 36.2%), and less likely to have ≥1 underlying condition (66.4% vs 78.5%) or be obese (21.4% vs 42.2%), and a shorter hospital stay (median, 5 days vs 7 days). They were similarly likely to require invasive mechanical ventilation (both 30.2%), vasopressor support (19.6% and 19.9%), or extracorporeal membrane oxygenation (2.2% and 2.9%). Four children with influenza (2.2%) and 11 children with COVID-19 (2.9%) died. The odds of death or requiring life support in children with influenza vs COVID-19 were similar (adjusted odds ratio, 1.30; 95% confidence interval, .78–2.15; P = .32). Conclusions Despite differences in demographics and clinical characteristics of children with influenza or COVID-19, the frequency of life-threatening complications was similar. Our findings highlight the importance of implementing prevention measures to reduce transmission and disease severity of influenza and COVID-19.
A Description of COVID-19-Directed Therapy in Children Admitted to US Intensive Care Units 2020
Schuster, Jennifer E. , Halasa, Natasha , Nakamura, Mari , Levy, Emily R. , Young, Cameron C. , Newhams, Margaret M. , Bourgeois, Florence T. , Staat, Mary Allen , Hobbs, Charlotte V. , Feldstein, Leora R. , Jackson, A. , Mack, Elizabeth H. , Walker, Tracie C. , Spinella, Philip C. , Loftis, Laura L. , Kong, Michele , Rowan, Courtney M. , McLaughlin, Gwenn E., Hall, Mark W. , Babbitt, Christopher , Maamari, Mia , Zinter, Matt S. , Gertz, Shira J. , Carroll, Christopher L. , Singh, Aalok R. , Hymes, Saul , Schwarz, Adam J. , McGuire, John K. , Nofziger, Ryan A. , Flori, Heidi R. , Clouser, Katharine N. , Wellnitz, Kari , Cullimore, Melissa L. , Hume, Janet R. , Patel, Manish , Randolph, Adrienne G. , Investigators, Overcoming COVID-19, Patel, Manish R. , Feldstein, Leora R , Levy, Emily R , Young, Cameron C , Randolph, Adrienne G , Spinella, Philip C , Kong, Michele , Hume, Janet R , Hobbs, Charlotte V , Staat, Mary A , Gertz, Shira J , Hymes, Saul R , Fitzgerald, Julie C. , Dapul, Heda , Jackson, Ashley M, Maddux, Aline B. , Bembea, Melania M. , Cvijanovich, Natalie Z , Michelson, Kelly Nicole , Thomas, Neal J. , Giuliano, John S. , Investigators, Overcoming COVID-19
Journal of the Pediatric Infectious Diseases Society | November 17, 2021 | Volume: 11 | Issue: 5 | Pages: 191-198
Abstract Background It is unclear how acute coronavirus disease 2019 (COVID-19)-directed therapies are used in children with life-threatening COVID-19 in US hospitals. We described characteristics of children hospitalized in the intensive care unit or step-down unit (ICU/SDU) who received COVID-19-directed therapies and the specific therapies administered. Methods Between March 15, 2020 and December 27, 2020, children <18 years of age in the ICU/SDU with acute COVID-19 at 48 pediatric hospitals in the United States were identified. Demographics, laboratory values, and clinical course were compared in children who did and did not receive COVID-19-directed therapies. Trends in COVID-19-directed therapies over time were evaluated. Results Of 424 children in the ICU/SDU, 235 (55%) received COVID-19-directed therapies. Children who received COVID-19-directed therapies were older than those who did not receive COVID-19-directed therapies (13.3 [5.6-16.2] vs 9.8 [0.65-15.9] years), more had underlying medical conditions (188 [80%] vs 104 [55%]; difference = 25% [95% CI: 16% to 34%]), more received respiratory support (206 [88%] vs 71 [38%]; difference = 50% [95% CI: 34% to 56%]), and more died (8 [3.4%] vs 0). Of the 235 children receiving COVID-19-directed therapies, 172 (73%) received systemic steroids and 150 (64%) received remdesivir, with rising remdesivir use over the study period (14% in March/April to 57% November/December). Conclusion Despite the lack of pediatric data evaluating treatments for COVID-19 in critically ill children, more than half of children requiring intensive or high acuity care received COVID-19-directed therapies.
Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome
LaRovere, Kerri L. , Riggs, Becky J. , Young, Cameron C. , Newhams, Margaret M. , Maamari, Mia , Walker, Tracie C. , Singh, Aalok R. , Dapul, Heda , Hobbs, Charlotte V. , McLaughlin, Gwenn E., Maddux, Aline B. , Clouser, Katharine N. , Rowan, Courtney M. , McGuire, John K. , Gertz, Shira J. , Muñoz, Álvaro Coronado , Irby, Katherine , Levy, Emily R. , Staat, Mary Allen , Feldstein, Leora R. , Halasa, Natasha , Hall, Mark W. , Kong, Michele , Carroll, Christopher L. , Schuster, Jennifer E. , Doymaz, Sule , Loftis, Laura L. , Tarquinio, Keiko M. , Babbitt, Christopher , Nofziger, Ryan A. , Kleinman, Lawrence C. , Keenaghan, Michael , Spinella, Philip C. , Hume, Janet R. , Wellnitz, Kari , Mack, Elizabeth H. , Flori, Heidi R. , Patel, Manish M. , Randolph, Adrienne G. , Investigators, Overcoming COVID-19, Name, First Name and Middle Initial Last, Gaspers, Mary Glas , Typpo, Katri , Sanders, Ronald C., Schwarz, Adam J. , Harvey, Helen , Mourani, Peter M. , Coates, Bria M. , Bhoojhawon, Guru , Havlin, Kevin , Sullivan, Janice E, Bradford, Tamara T. , Lipton, Susan V., Chen, Sabrina , Kücükak, Suden, Carroll, Ryan W. , Fernandes, Neil D. , Yager, Phoebe H. , Marohn, Kimberly L, Heidemann, Sabrina M. , Cullimore, Melissa L. , Horwitz, Steven M. , Walsh, Rowan, Soma, Vijaya L, Gillen, Jennifer , Zackai, Sheemon, Ackerman, Kate G. , Cholette, Jill M., Hymes, Saul , Overby, Philip , Schwartz, Stephanie P. , Lansell, Amanda , Koncicki, Monica L. , Carcillo, Joseph A. , Bowens, Cindy , Crandall, Hillary , Smith, Lincoln , Cengiz, Pelin , Levy, Emily R , Young, Cameron C , Randolph, Adrienne G , Spinella, Philip C , Kong, Michele , Hume, Janet R , Hobbs, Charlotte V , Maddux, Aline B , Staat, Mary A , Gertz, Shira J , Schwartz, Stephanie P , Hymes, Saul R , Poussaint, Tina Young , Son, Mary Beth F. , Fitzgerald, Julie C. , Shein, Steven L. , Thomas, Neal J. , Tenforde, Mark W. , Giuliano, John S. , Cvijanovich, Natalie Z , Michelson, Kelly Nicole , Investigators, Overcoming COVID-19, Zinter, Matt S. , Montgomery, Vicki , Sullivan, Janice E, Bembea, Melania M. , Graciano, Ana Lía , Newburger, Jane W. , Marohn, Kimberly L, McCulloh, Russell J. , Li, Simon , Ratner, Adam J. , Harwayne‐Gidansky, Ilana , Fink, Ericka L. , Kimura, Dai
JAMA Neurology | March 5, 2021 | Volume: 78 | Issue: 5 | Pages: 536