Citations 12
Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium
Smedby, Karin E. , Vajdic, Claire M. , Falster, Michael O. , Martı́nez-Maza, Otoniel , Turner, Jennifer , Hjalgrim, Henrik , Vineis, Paolo , Costantini, Adele Seniori , Bracci, Paige M. , Holly, Elizabeth A., Willett, Eleanor V., Spinelli, John J., Vecchia, Carlo La , Zheng, Tongzhang, Becker, Nikolaus, Sanjosé, Sílvia de , Maso, Luigino Dal , Cocco, Pierluigi , Foretová, Lenka , Staines, Anthony , Brennan, Paul , Severson, Richard K., Cerhan, James R. , Breen, Elizabeth C. , Birmann, Brenda M. , Grulich, Andrew E. , Kane, Eleanor , Engels, Eric A. , Chiu, Brian C.‐H. , Maynadié, Marc , Davis, Scott , Cozen, Wendy , Cerhan, James R , Turner, Jennifer , Cocco, Pierluigi , Vajdic, Claire M , Kane, Eleanor , Martínez-Maza, Otoniel , Birmann, Brenda M
Blood | February 8, 2008 | Volume: 111 | Issue: 8 | Pages: 4029-4038
Abstract Some autoimmune disorders are increasingly recognized as risk factors for non-Hodgkin lymphoma (NHL) overall, but large-scale systematic assessments of risk of NHL subtypes are lacking. We performed a pooled analysis of self-reported autoimmune conditions and risk of NHL and subtypes, including 29 423 participants in 12 case-control studies. We computed pooled odds ratios (OR) and 95% confidence intervals (CI) in a joint fixed-effects model. Sjögren syndrome was associated with a 6.5-fold increased risk of NHL, a 1000-fold increased risk of parotid gland marginal zone lymphoma (OR = 996; 95% CI, 216-4596), and with diffuse large B-cell and follicular lymphomas. Systemic lupus erythematosus was associated with a 2.7-fold increased risk of NHL and with diffuse large B-cell and marginal zone lymphomas. Hemolytic anemia was associated with diffuse large B-cell NHL. T-cell NHL risk was increased for patients with celiac disease and psoriasis. Results for rheumatoid arthritis were heterogeneous between studies. Inflammatory bowel disorders, type 1 diabetes, sarcoidosis, pernicious anemia, and multiple sclerosis were not associated with risk of NHL or subtypes. Thus, specific autoimmune disorders are associated with NHL risk beyond the development of rare NHL subtypes in affected organs. The pattern of associations with NHL subtypes may harbor clues to lymphomagenesis.
Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph)
Wang, Sophia , Brennan, Paul , Holly, Elizabeth A., Sanjosé, Sílvia de, Cerhan, James R. , Spinelli, John J., Cocco, Pier Luigi, Mensah, Fiona , Nieters, Alexandra, Maso, Luigino Dal , Bracci, Paige M. , Costantini, Adele Seniori , Vineis, Paolo , Severson, Richard K., Roman, Eve , Weisenburger, Dennis D. , Franceschi, Silvia , Vecchia, Carlo La , Foretová, Lenka , Becker, Nikolaus, Staines, Anthony , Vornanen, Martine, Zheng, Tongzhang, Hartge, Patricia, Cocco, Pierluigi , Slager, Susan L. , Bernstein, Leslie , Boffetta, Paolo , Maynadié, Marc , Chiu, Brian C.‐H. , Zhang, Yawei , Cozen, Wendy , Davis, Scott , Cerhan, James R , Cocco, Pierluigi , Wang, Sophia S , Roman, Eve
Blood | December 22, 2006 | Volume: 109 | Issue: 8 | Pages: 3479-3488
AbstractA role for genetic susceptibility in non-Hodgkin lymphoma (NHL) is supported by the accumulating evidence of common genetic variations altering NHL risk. However, the pattern of NHL heritability remains poorly understood. We conducted a pooled analysis of 10 211 NHL cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph) to evaluate NHL risk among those with hematopoietic malignancies in first-degree relatives. Odds ratios (ORs) and 95% confidence intervals (CIs) of NHL and its subtypes were estimated from unconditional logistic regression models with adjustment for confounders. NHL risk was elevated for individuals who reported first-degree relatives with NHL (OR = 1.5; 95% CI = 1.2-1.9), Hodgkin lymphoma (OR = 1.6; 95% CI = 1.1-2.3), and leukemia (OR = 1.4; 95% CI = 1.2-2.7). Risk was highest among individuals who reported a brother with NHL (OR = 2.8; 95% CI = 1.6-4.8) and was consistent for all NHL subtypes evaluated. If a first-degree relative had Hodgkin lymphoma, NHL risk was highest if the relative was a parent (OR = 1.7; 95% CI = 1.0-2.9). If a first-degree relative had leukemia, NHL risk was highest among women who reported a sister with leukemia (OR = 3.0; 95% CI = 1.6-5.6). The pattern of NHL heritability appeared to be uniform across NHL subtypes, but risk patterns differed by specific hematopoietic malignancies and the sex of the relative, revealing critical clues to disease etiology.