Citations 52
S2–02–06: The tauopathies: From genetics to animal models
Hutton, Mike, Melquist, Stacey , Zehr, Cynthia, Eriksen, Jason L. , Stephan, Dietrich A. , Lewis, Jada , Baker, Matthew , McGowan, Eileen , Dickson, Dennis W. , Ashe, Karen H.
Alzheimer's & Dementia | August 17, 2006 | Volume: 2 | Issue: 3S_Part_1 | Pages: No page available
Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees
Ertekin‐Taner, Nilüfer , Younkin, Linda H., Eckman, Christopher B., Adamson, Jennifer, Hutton, Michael , Younkin, Steven G., Graff, Caroline , Baker, Matthew , Ronald, James , Blangero, John
Science | July 27, 2002 | Volume: 290 | Issue: 5500 | Pages: 2303-2304
Plasma Aβ42 (amyloid β42 peptide) is invariably elevated in early-onset familial Alzheimer's disease (AD), and it is also increased in the first-degree relatives of patients with typical late-onset AD (LOAD). To detect LOAD loci that increase Aβ42, we used plasma Aβ42 as a surrogate trait and performed linkage analysis on extended AD pedigrees identified through a LOAD patient with extremely high plasma Aβ. Here, we report linkage to chromosome 10 with a maximal lod score of 3.93 at 81 centimorgans close to D10S1225. Remarkably, linkage to the same region was obtained independently in a genome-wide screen of LOAD sibling pairs. These results provide strong evidence for a novel LOAD locus on chromosome 10 that acts to increase Aβ.